Bioactive Microbial Metabolites

Specialized Bioactive Microbial Metabolites: From Gene to Product

1Department of Biotechnology and Life Sciences, University of Insubria andThe Protein Factory, Interuniversity Centre Politecnico di Milano, ICRM CNR Milano and University of Insubria, Varese, Italy 2Fundación MEDINA, Health Sciences Technology Park, Granada, Spain 3Department of Genetics and Biotechnology, Ivan Franko National University of Lviv, Ukraine 4Department of Molecular Microbiology a...

Microbial technologies for the discovery of novel bioactive metabolites.

Soil microbes represent an important source of biologically active compounds. These molecules present original and unexpected structure and are selective inhibitors of their molecular targets. At Biosearch Italia, discovery of new bioactive molecules is mostly carried out through the exploitation of a proprietary strain collection of over 50000 strains, mostly unusual genera of actinomycetes an...

Bioactive metabolites from marine invertebrates

Recent results in the chemistry of bioactive marine products are presented. Concerning the cytotoxic a-carbolines : grossularins A and B, the mechanism of the toxicity using supercoiled DNA and synthesis of the imidazolo-a-carboline moiety are presented. In the polysulfur compounds series, the structure of lissoclinotoxin B is proposed as well as a new synthesis of pentathiepins. Novel sesquite...

Bioactive metabolites from Spilanthes acmella Murr.

Spilanthes acmella Murr. (Compositae) has been used as a traditional medicine for toothache, rheumatism and fever. Its extracts had been shown to exhibit vasorelaxant and antioxidant activities. Herein, its antimicrobial, antioxidant and cytotoxic activities were evaluated. Agar dilution method assays against 27 strains of microorganisms were performed. Results showed that fractions from the ch...

Bioactive secondary metabolites from Juncaceae species